| Identification | Back Directory | [Name]
ketanserinol | [CAS]
76330-73-9 | [Synonyms]
R-46742
ketanserinol
Reduced ketanserin
3-[2-[4-[(4-Fluorophenylcarbonyl)(hydroxy)methyl]piperidin-1-yl]ethyl]-2,4(1H,3H)-quinazolinedione | [MOL File]
76330-73-9.mol |
| Hazard Information | Back Directory | [Description]
Ketanserinol is the metabolite of ketanserin, a hypotensive drug with 5-HT2 receptor antagonism. Ketanserin is used to reverse pulmonary hypertension caused by protamine. | [Uses]
Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562). Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The KB values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries[1]. | [References]
[1] Frenken M, et al. Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):334-9. DOI:10.1007/BF00501438 |
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