| Identification | Back Directory | [Name]
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE | [CAS]
76360-82-2 | [Synonyms]
NSC 165300
-2-(methylsulfanyl)
Ethyl 4-(methylamino)
-5-pyrimidinecarboxylate
Ethyl 4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxylate
2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylic acid e
ethyl 2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylate
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
ethyl 4-(MethylaMino)-2-(Methylsulfanyl)pyriMidine-5-carboxylate
4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid Ethyl Ester
4-MethylaMino-2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester
2-(methylthio)-4-(methylamino)-pyrimidine-5-carboxylic acid ethyl ester
5-Pyrimidinecarboxylic acid, 4-(methylamino)-2-(methylthio)-, ethyl ester
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ISO 9001：2015 REACH | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C9H13N3O2S | [MDL Number]
MFCD00476788 | [MOL File]
76360-82-2.mol | [Molecular Weight]
227.28 |
| Chemical Properties | Back Directory | [Melting point ]
91-93 °C | [Boiling point ]
368.9±22.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol | [form ]
Solid | [pka]
3.11±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
An intermediate in the preparation of antitumor agents, antiinflammatory agents and tyrosine kinase inhibitors | [Synthesis]
A 33% aqueous methylamine solution (17.5 mL, 140 mmol) was slowly added dropwise to a dichloromethane solution (120 mL) containing ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (10.0 g, 43.1 mmol) at 0 °C. The reaction mixture was stirred at this temperature for 30 minutes. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, it was quenched by the addition of water (150 mL), the organic phase was separated and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford the product ethyl 4-methylamino-2-methylthio-5-pyrimidinecarboxylate (9.77 g, 100% yield) as a white solid. | [References]
[1] Patent: WO2014/144737, 2014, A1. Location in patent: Paragraph 00719
[2] Patent: WO2015/19037, 2015, A1. Location in patent: Page/Page column 87; 88
[3] Patent: US2003/207900, 2003, A1. Location in patent: Page/Page column 15
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5439 - 5448
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2255 - 2265 |
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