765-39-9

885-12-1

765-39-9

Step 2: Synthesis of 1H-pyrrol-1-amine To a solution of 2-(1H-pyrrol-1-yl)isoindoline-1,3-dione (3.5 g, 0.016 mmol) in methanol (35 mL) was added hydrazine monohydrate (1 mL, 0.021 mmol). The reaction mixture was heated to 65 °C and kept for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and filtered. The collected solid was washed with methanol, the filtrate was combined and concentrated to give a light yellow solid. The solid was ground with ether and then the organic solution was concentrated to give 1-aminopyrrole as a brown oil (1 g, 74% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 5.84 (t, J = 2.0 Hz, 2H), 5.86 (d, exchangeable with D2O, 2H), 6.62 (t, J = 2.0 Hz, 2H).