| Identification | Back Directory | [Name]
PHOSPHATIDYLETHANOL | [CAS]
765260-45-5 | [Synonyms]
PHOSPHATIDYLETHANOL
1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL | [Molecular Formula]
C41H79O9P | [MDL Number]
MFCD00211162 | [MOL File]
765260-45-5.mol | [Molecular Weight]
747.03 |
| Chemical Properties | Back Directory | [storage temp. ]
-20° | [solubility ]
Soluble in Chloroform (up to 10 mg/ml). | [form ]
Viscous oil / waxy solid | [Stability:]
Stable for 2 years from date of purchase as supplied. Phosphatidylethanol is subject to oxidation and must be protected from exposure to air. Solutions in chloroform may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Phosphatidlyethanol is an endogenous metabolite of phosphatidylcholine. Phospholipase D converts phosphatidylcholine to phosphatidylethanol in the presence of ethanol. This reaction is the basis of a sensitive and selective assay for PLD activity in intact cells for which this product may be used as a chromatographic standard. | [References]
1) Kobayashi et al. (1987), Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D; J. Neurochem., 48 1597
2) Liscovith et al. (1989), Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C; J. Biol. Chem., 264 1450
3) Pai et al. (1988), Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes; J. Biol. Chem., 263 12472 |
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