767287-99-0

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767287-99-0 Structure

Identification	Back Directory
[Name] Z-DQMD-FMK
[CAS] 767287-99-0
[Synonyms] Z-DQMD-FMK Z-D(OME)QMD(OME)-FMK CASPASE-3 INHIBITOR V Z-ASP(OME)-GLN-MET-ASP(OME)-FMK Z-D(OME)QMD(OME) (FLUOROMETHYLKETONE) Z-DQMD-FMK, Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK Z-ASP(OME)-GLN-MET-ASP(OME)-FLUOROMETHYLKETONE Z-ASP(OME)-GLN-MET-DL-ASP(OME)-FLUOROMETHYLKETONE BENZYLOXYCARBONYL-ASP(OME)-GLN-MET-ASP(OME)-FLUOROMETHYLKETONE L-Methioninamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-glutaminyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
[Molecular Formula] C29H40FN5O11S
[MDL Number] MFCD03452876
[MOL File] 767287-99-0.mol
[Molecular Weight] 685.72

Chemical Properties	Back Directory
[storage temp. ] −20°C
[solubility ] ≥29.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
[form ] powder
[color ] white

Safety Data	Back Directory
[WGK Germany ] 3

Hazard Information	Back Directory
[Uses] Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK is an inhibitor for caspase-3, and inhibits Dihydroartemisinin (HY-N0176) and Dictamnine (HY-N0849) co-induced apoptosis[1].
[Biological Activity] Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro .
[References] 1. susan s. chou*, michael s. clegg, alterations in protein kinase c activity and processing during zinc-de?ciency-induced cell death, biochem. j. (2004) 383, 63–71 2. j. h. banga, e. s. han. differential response of mg132 cytotoxicity against small cell lung cancer cells to changes in cellular gsh contents. biochemical pharmacology 68 (2004) 659–666. 3. t. shimohata, h. zhao, εpkc may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. stroke. 2007;38:375-380

Spectrum Detail	Back Directory
[Spectrum Detail] Z-DQMD-FMK(767287-99-0)MS

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