| Identification | Back Directory | [Name]
Benzamide, 2-[(butylsulfonyl)amino]-N-[(1R)-1-(6-methoxy-3-pyridinyl)propyl]- | [CAS]
767334-89-4 | [Synonyms]
A293
AVE1231
Benzamide, 2-[(butylsulfonyl)amino]-N-[(1R)-1-(6-methoxy-3-pyridinyl)propyl]- | [Molecular Formula]
C20H27N3O4S | [MOL File]
767334-89-4.mol | [Molecular Weight]
405.51 |
| Hazard Information | Back Directory | [Uses]
AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation[1][2]. | [References]
[1] Wiedmann F, et al. Identification of the A293 (AVE1231) binding site in the cardiac two-pore-domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site[J]. Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, 52(5). DOI:10.33594/000000083
[2] Wirth K J, et al. In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231[J]. Journal of cardiovascular pharmacology, 2007, 49(4): 197-206. DOI:10.1097/FJC.0b013e318032002f |
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