768404-03-1

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768404-03-1 Structure

Identification	Back Directory
[Name] 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
[CAS] 768404-03-1
[Synonyms] 5-BDBD 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one 2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, 5-(3-bromophenyl)-1,3-dihydro-
[Molecular Formula] C17H11BrN2O2
[MDL Number] MFCD18086878
[MOL File] 768404-03-1.mol
[Molecular Weight] 355.19

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMSO: soluble15mg/mL (clear solution)
[form ] powder
[color ] white to beige
[InChI] InChI=1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
[InChIKey] NKYMVQPXXTZHSF-UHFFFAOYSA-N
[SMILES] N1=C(C2=CC=CC(Br)=C2)C2OC3=CC=CC=C3C=2NC(=O)C1

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302
[Precautionary statements ] P264-P270-P301+P312-P330-P501
[Hazard Codes ] Xn
[Risk Statements ] 22
[WGK Germany ] 3
[Storage Class] 11 - Combustible Solids

[Uses]

5-BDBD is a potent P2X4 receptor antagonist.

[Biochem/physiol Actions]

5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC50 of 500 nM.

[in vivo]

5-BDBD (28 mg/kg; i.p.; daily for 9 days) can completely blocke the basal hyperalgesia induced by recurrent NTG injection^[2].

Animal Model:	Male C57BL/6 mice^[2]
Dosage:	28 mg/kg
Administration:	I.p.; daily for 9 days
Result:	Prevented NTG-induced mechanical hypersensitivity.

[IC 50]

P2X4 Receptor

[storage]

Store at RT

Spectrum Detail	Back Directory
[Spectrum Detail] 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one(768404-03-1)¹HNMR

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