| Chemical Properties | Back Directory | [Boiling point ]
327.7±32.0 °C(predicted) | [density ]
1.477±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
12.15±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
SMARCA2/4-IN-1 (compound 1) is a potent SMARCA2 inhibitor with IC50 values of 3.8, 1.7 μM for SMARCA2, SMARCA4, respectively[1]. | [References]
[1] Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172. DOI:10.1021/acs.jmedchem.8b01318 |
|
|