| Identification | Back Directory | [Name]
24(S),25-Epoxycholesterol (not deuterated) | [CAS]
77058-74-3 | [Synonyms]
24(S)
24S,25-EpoxyC
25-epoxycholesterol
(24S)-24,25-Epoxycholestero
(24S)-24,25-Epoxycholesterol
(24S)-24,25-Epoxycholest-5-en-3β-ol
24(S),25-Epoxycholesterol (not deuterated)
Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-
24(S),25-EPOXYCHOLESTEROL;24(S);25-EPOXYCHOLESTEROL | [Molecular Formula]
C27H44O2 | [MOL File]
77058-74-3.mol | [Molecular Weight]
400.64 |
| Chemical Properties | Back Directory | [Melting point ]
156-157 °C | [Boiling point ]
496.4±18.0 °C(predicted) | [density ]
1.05 | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 30 mg/ml). | [form ]
White solid. | [pka]
15.03±0.70(predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ. It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM. | [Uses]
(24S)-24,25-Epoxycholesterol is a derivative of 4β-Hydroxy Cholesterol (H917980), a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. | [Definition]
ChEBI: A 3beta-hydroxy steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor. | [in vivo]
24S,25-Epoxycholesterol (5 mM, icv) enhances the mDA neurogenesis, limits the neurodegeneration in CYP46A1-overexpressing mice midbrain[4]. | Animal Model: | GGPP induced mDA neurogenesis defect in CYP46A1 overexpressing CD-1 mice[4] | | Dosage: | 5 mM | | Administration: | icv, 1 μL, single dosage | | Result: | Increased levels of mDA neurons, blocked the GGPP induced decrease of double EdU and TH cells. |
| [storage]
Store at -20°C | [References]
1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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