| Identification | Back Directory | [Name]
1H-Purine-2,6-dione, 3-[2-(4-aminophenyl)ethyl]-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]-3,7-dihydro-8-(phenylmethyl)-1-propyl- | [CAS]
770703-20-3 | [Synonyms]
L97-1
L 97-1
L-97-1
L971,L 97 1
1H-Purine-2,6-dione, 3-[2-(4-aminophenyl)ethyl]-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]-3,7-dihydro-8-(phenylmethyl)-1-propyl- | [Molecular Formula]
C29H38N6O3 | [MDL Number]
MFCD09832682 | [MOL File]
770703-20-3.mol | [Molecular Weight]
518.65 |
| Hazard Information | Back Directory | [Uses]
L-97-1 is a A1 adenosine receptor (A1AR) antagonist. L-97-1 is a water-soluble small molecule compound with high affinity and high selectivity against human A1 adenosine receptors. L-97-1 works by blocking A1 adenosine receptors. In patients with asthma, adenosine is an important signaling molecule capable of causing bronchoconstriction by activating A1AR. L-97-1 reduces airway hyperreactivity (BHR) by competitively binding to A1AR, thereby alleviating or blocking adenosine-induced bronchoconstriction and inflammation[1]. | [References]
[1] Obiefuna P C M, et al. A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3, 7-dihydro-purine-2, 6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315(1): 329-336. DOI:10.1124/jpet.105.088179 |
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