| Identification | Back Directory | [Name]
L-Tryptophan, L-tryptophyl-L-leucyl-L-seryl-L-α-glutamyl-L-alanylglycyl-L-prolyl-L-valyl-L-valyl-L-threonyl-L-valyl-L-arginyl-L-alanyl-L-leucyl-L-arginylglycyl-L-threonylglycyl-L-seryl- | [CAS]
771479-86-8 | [Synonyms]
WLSEAGPVVTVRALRGTGSW
L-Tryptophan, L-tryptophyl-L-leucyl-L-seryl-L-α-glutamyl-L-alanylglycyl-L-prolyl-L-valyl-L-valyl-L-threonyl-L-valyl-L-arginyl-L-alanyl-L-leucyl-L-arginylglycyl-L-threonylglycyl-L-seryl- | [Molecular Formula]
C97H152N28O27 | [MOL File]
771479-86-8.mol | [Molecular Weight]
2142.45 |
| Hazard Information | Back Directory | [Uses]
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte specific peptide. WLSEAGPVVTVRALRGTGSW-expressing exosomes can improve specific uptake by cardiomyocytes, decrease cardiomyocyte apoptosis, and enhance cardiac retention following intramyocardial injection in vivo[1][2]. | [References]
[1] McGuire MJ, et, al. In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo. J Mol Biol. 2004 Sep 3;342(1):171-82. DOI:10.1016/j.jmb.2004.06.029
[2] Mentkowski KI, et, al. Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo. Sci Rep. 2019 Jul 11;9(1):10041. DOI:10.1038/s41598-019-46407-1 |
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