| Identification | Back Directory | [Name]
CROCONAZOLE | [CAS]
77175-51-0 | [Synonyms]
Pilzcin
710674-S
CROCONAZOLE
CLOCONAZOLE
Viniconazole
CROCONAZOLE USP/EP/BP
Croconazole (Cloconazole)
1-[1-[2-(3-Chlorobenzyloxy)phenyl]vinyl]-1H-imidazole
1-[1-[2-[(3-Chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole
1-[1-[2-[(3-Chlorobenzyl)oxy]phenyl]ethenyl]-1H-imidazole
1-(1H-Imidazole-1-yl)-1-[2-(3-chlorobenzyloxy)phenyl]ethene
1-[1-[2-[(3-Chlorophenyl)methoxy]phenyl]ethenyl]-1H-imidazole
1H-Imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]- | [Molecular Formula]
C18H15ClN2O | [MDL Number]
MFCD00865578 | [MOL File]
77175-51-0.mol | [Molecular Weight]
310.78 |
| Chemical Properties | Back Directory | [Melting point ]
72-73℃ | [Boiling point ]
501.5±60.0 °C(Predicted) | [density ]
1.16 | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
6.29±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Soluble in ethyl acetate. Melting point 72-73°C. Cloconazole hydrochloride: C18H15ClN2O·HCl. [77174-66-4]. Crystallizes in ethyl acetate and acetonitrile, melting point 148.5-150°C. Acute toxicity LD50 rat (mg/kg): 7000 subcutaneously, 2500 orally. | [Uses]
Cloconazole is an antifungal azole drug. | [Definition]
ChEBI: Croconazole is an imidazole antifungal drug, a conazole antifungal drug, a member of monochlorobenzenes and an aromatic ether. | [Indications]
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. | [Antimicrobial activity]
Broad-spectrum imidazole antimycotic with activity against almost all pathogenic fungi. | [Side effects]
Local irritations and allergic reactions after topical treatment may occur in rare cases and are mainly due to the galenic formulation. | [Metabolic pathway]
When male rabbits are administered croconazole by
intravenous injection, as many as 16 metabolites are
excreted in the urine and 13 metabolites are identified.
The biotransformation reaction of croconazole includes
ring hydroxylation, O-dechlorobenzylation, and the loss
of the imidazole ring. |
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