| Identification | Back Directory | [Name]
2-(9H-fluorene-2-carbonyl)benzoic acid | [CAS]
77308-57-7 | [Synonyms]
NSC77053
NSC-77053
NSC 77053
2-(9H-fluorene-2-carbonyl)benzoic acid
Benzoic acid, 2-(9H-fluoren-2-ylcarbonyl)- | [Molecular Formula]
C21H14O3 | [MOL File]
77308-57-7.mol | [Molecular Weight]
314.33 |
| Hazard Information | Back Directory | [Description]
NSC-77053 is the first reported BoNT/E small molecule inhibitor. Botulinum neurotoxins (BoNT) are among the most poisonous substances known, and of the 7 serotypes (A-G) identified thus far at least 4 can cause death in humans. | [Uses]
NSC-77053 is a potent BoNT/E inhibitor with an IC50 and a Ki of 2.4 μM and 1.29 μM, respectively[1]. | [References]
[1] Yuchen Zhou, et al. Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity. Bioorg Med Chem. 2016 Oct 15;24(20):4875-4889. DOI:10.1016/j.bmc.2016.06.036 |
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