| Identification | Back Directory | [Name]
4-BROMO-1-CHLORO-2-IODOBENZENE | [CAS]
774608-49-0 | [Synonyms]
5-Bromo-2-chloroiodobenzene
2-Chloro-5-bromoiodobenzene
4-bromo-1-chloro-2-iodobenze
4-BROMO-1-CHLORO-2-IODOBENZENE
1-Bromo-4-chloro-3-iodobenzene
Benzene, 4-bromo-1-chloro-2-iodo- | [Molecular Formula]
C6H3BrClI | [MDL Number]
MFCD07780669 | [MOL File]
774608-49-0.mol | [Molecular Weight]
317.35 |
| Chemical Properties | Back Directory | [Boiling point ]
283.3±25.0 °C(Predicted) | [density ]
2.272±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
liquid | [color ]
Clear, yellow |
| Hazard Information | Back Directory | [Synthesis]
Example 187: Synthesis of 6-(5-bromo-2-chloro-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine. To a stirred solution of copper(II) chloride suspension (1.62 g, 12.0 mmol) and tert-butyl nitrite (15.0 mmol) in acetonitrile (40 ml) was heated to 60°C. Subsequently, an acetonitrile solution (10 ml) of 4-bromo-2-iodoaniline (2.98 g, 10.0 mmol) was added dropwise over 50 min. The reaction mixture was continued to be stirred at 60 °C for 1 hour. After completion of the reaction, the mixture was poured into 20% hydrochloric acid (200 ml) and extracted with ether (2 x 30 ml). The crude product was purified by rapid chromatography on silica gel using hexane as eluent to give 4-bromo-1-chloro-2-iodobenzene (2.4 g, 76% yield). | [References]
[1] Patent: US2004/204386, 2004, A1 |
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