| Identification | Back Directory | [Name]
BOC-LYS-OTBU | [CAS]
7750-42-7 | [Synonyms]
Boc-Lys-OtBu (Syrup)
N-Boc-Lysine Tert-butyl Ester
N2-Boc-L-lysine tert-butyl ester
(Tert-Butoxy)Carbonyl Lys-OtBu (Syrup)
tert-butyl N-tert-butyloxycarbonyl-L-lysinate
(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
tert-butyl (2S)-6-amino-2-{[(tert-butoxy)carbonyl]amino}hexanoate
L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H30N2O4 | [MDL Number]
MFCD28963513 | [MOL File]
7750-42-7.mol | [Molecular Weight]
302.41 |
| Chemical Properties | Back Directory | [Boiling point ]
406.7±40.0 °C(Predicted) | [density ]
1.021±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
Chloroform (Sparingly), Methanol (Sparingly) | [form ]
Solid | [pka]
11.16±0.46(Predicted) | [color ]
Off-White | [Optical Rotation]
7.867°(C=0.01g/ml CHCL3) | [InChI]
InChI=1S/C15H30N2O4/c1-14(2,3)20-12(18)11(9-7-8-10-16)17-13(19)21-15(4,5)6/h11H,7-10,16H2,1-6H3,(H,17,19)/t11-/m0/s1 | [InChIKey]
LVUBESNUUMLEHL-NSHDSACASA-N | [SMILES]
C(OC(C)(C)C)(=O)[C@H](CCCCN)NC(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Uses]
N-Boc-Lysine Tert-butyl Ester is used in preparation of Tetrahydroisoquinoline derivatives as blood coagulation factor inhibitors useful in the treatment of thromboembolic disorders. | [Synthesis]
General procedure for the synthesis of (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester from (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester: (0133) (0134) (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester was butyl ester (98.8 mg, 0.226 mmol) and 10% Pd/C (12.1 mg, 11.4 μmol) were dissolved in methanol (1 mL) and stirred for 2 h at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford tert-butyl (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoate in 96% (66.1 mg) yield. The resulting product was used directly in the next reaction without further purification. | [References]
[1] Angewandte Chemie - International Edition, 2009, vol. 48, # 9, p. 1633 - 1635
[2] Patent: EP2952504, 2015, A1. Location in patent: Paragraph 0133-0134
[3] Tetrahedron Letters, 2014, vol. 55, # 46, p. 6343 - 6346
[4] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 15, p. 3957 - 3965
[5] Journal of the American Chemical Society, 1997, vol. 119, # 17, p. 4086 - 4087 |
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| Company Name: |
commedx Gold
|
| Telephone: |
1851900025 |
| Website: |
www.commedx.com |
| Company Name: |
Shanghai GL Peptide Ltd.
|
| Telephone: |
+86-21-61263310 13764994101 |
| Website: |
www.chemicalbook.com/supplier/10480342/ |
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