| Identification | Back Directory | [Name]
BRN 4488383 | [CAS]
77529-42-1 | [Synonyms]
BRN 4488383
Glycolic acid oxidase inhibitor 1
4-(4'-Bromo-4-biphenylyl)-5-hydroxy-1H-pyrrole-2,3-dione
3-[4'-Bromo(1,1'-biphenyl)-4-yl]-4-hydroxy-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-(4'-bromo[1,1'-biphenyl]-4-yl)-4-hydroxy- | [Molecular Formula]
C16H10BrNO3 | [MDL Number]
MFCD01688397 | [MOL File]
77529-42-1.mol | [Molecular Weight]
344.16 |
| Chemical Properties | Back Directory | [Melting point ]
326-328 °C (decomp) | [Boiling point ]
528.9±50.0 °C(Predicted) | [density ]
1.641±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 137 mg/mL (398.07 mM) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV. | [in vivo]
Glycolic acid oxidase inhibitor 1 inhibits oxalate biosynthesis in isolated perfused rat liver. Glycolate oxidase inhibitors provide a specific approach to the prevention and treatment of calcium oxalate renal lithiasis[1]. | [References]
[1] Cragoe Jr., Edward J, et al. 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione compounds, process for their preparation and pharmaceutical compositions containing the same.EP0021228A1. |
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