| Identification | Back Directory | [Name]
MAFENIDE ACETATE | [CAS]
7761-27-5 | [Synonyms]
MAFENIDE
MARFANIL
MAFENAMIDE ACETATE
MARFANIL ACETATE SALT
MAFENIDE ACETATE SALT
4-HOMOSULFANILAMIDE ACETATE
4-HOMOSULFANILAMIDE ACETATE SALT
P-(AMINOMETHYL) BENZENESULFONAMIDE ACETATE
ALPHA-AMINO-P-TOLUENSULFONAMIDE MONOACETATE
P-AMINOMETHYLBENZENESULFONAMIDE ACETATE SALT
4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE | [EINECS(EC#)]
235-855-0 | [Molecular Formula]
C9H14N2O4S | [MDL Number]
MFCD00072089 | [MOL File]
7761-27-5.mol | [Molecular Weight]
246.28 |
| Hazard Information | Back Directory | [Indications]
Mafenide (Sulfamylon) is a synthetic antibacterial agent related chemically, but
not pharmacologically, to the sulfonamides. The drug appears to interfere with
bacterial cellular metabolism and is not antagonized by PABA, pus, or serum. It is
bacteriostatic against many gram-positive and gram-negative organisms, including
staphylococci, streptococci, and Pseudomonas species. Mafenide is highly soluble
and diffuses easily through an eschar. After percutaneous absorption, the drug is
metabolized; it acts as a weak carbonic anhydrase inhibitor and may therefore cause
systemic acidosis.
Mafenide is used primarily in the adjunctive treatment of second- and thirddegree
burn wounds. It may cause severe pain on application, and active allergic
contact sensitivity may develop. |
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