| Identification | Back Directory | [Name]
Metoprine | [CAS]
7761-45-7 | [Synonyms]
DDMP
U-197
BW 197U
SK 5265
NSC 7364
Metoprine
BW-50-197
NSC-19494
methodichlorophen
2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE
5-(3,4-dichlorophenyl)-6-MethylpyriMidine-2,4-diaMine
5-(3,4-Dichlorophenyl)-6-Methyl-2,4-pyriMidinediaMine | [Molecular Formula]
C11H10Cl2N4 | [MDL Number]
MFCD00866407 | [MOL File]
7761-45-7.mol | [Molecular Weight]
269.13 |
| Chemical Properties | Back Directory | [Melting point ]
275-276℃ | [Boiling point ]
418.42°C (rough estimate) | [density ]
1.447 | [refractive index ]
1.6300 (estimate) | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
6.80±0.10(Predicted) | [color ]
Off-White to Light Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
A 2,4-Diaminopyrimidine derivative as antimalarial agent. | [in vivo]
Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner[2].
Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption[1].
| Animal Model: | Male Sprague-dawley rats (200-280g)[2] | | Dosage: | 2, 5, 10 mg/kg | | Administration: | IP | | Result: | Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg.
|
| [storage]
Store at -20°C |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|