| Identification | Back Directory | [Name]
PROTAC ABL binding moiety 2 | [CAS]
778277-37-5 | [Synonyms]
GNF5-amido-Me
PROTAC ABL binding moiety 2
Benzamide, N-methyl-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]- | [Molecular Formula]
C19H15F3N4O2 | [MDL Number]
MFCD32062715 | [MOL File]
778277-37-5.mol | [Molecular Weight]
388.34 |
| Hazard Information | Back Directory | [Uses]
GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1]. | [References]
[1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284 |
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