77925-80-5

2687-43-6

1694-92-4

77925-80-5

A solution of 2-nitrobenzene-1-sulfonyl chloride (500 g, 2.26 mol) in pyridine (1500 mL) was slowly added dropwise to a solution of O-benzylhydroxylamine hydrochloride (400 g, 2.51 mol) in pyridine (1500 mL) at 0 °C. The reaction mixture was then stirred at 20 °C overnight. After completion of the reaction, the mixture was concentrated under reduced pressure, diluted with dichloromethane (DCM) and washed three times with 10% hydrochloric acid solution. After combining the organic layers, the mixture was again concentrated under reduced pressure and recrystallized by dichloromethane to give N-(benzyloxy)-2-nitrobenzenesulfonamide as a yellow solid (485 g, 62.6% yield).