| Identification | Back Directory | [Name]
BETA-PHENYL-1,N2-ETHENOGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT | [CAS]
78080-27-0 | [Synonyms]
PET-CGMP
PET-CGMP SODIUM SALT
BETA-PHENYL-1,N2-ETHENOGUANOSINE-3',5'-MONOPHOSPHATE SODIUM SALT
β-Phenyl-1,N2-ethenoguanosine 3μ,5μ-monophosphate sodium salt
BETA-PHENYL-1,N2-ETHENOGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
?phenyl-1,n?ethenoguanosine-3’,5’-cyclicmonophosphate(pet-cgmp),sodiumsalt
9H-Imidazo[1,2-a]purin-9-one,3,4-dihydro-6-phenyl-3-(3,5-O-phosphinico-b-D-ribofuranosyl)- (9CI)
3-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-5H-imidazo[1,2-a]purin-9-one | [Molecular Formula]
C18H15N5NaO7P | [MDL Number]
MFCD04118064 | [MOL File]
78080-27-0.mol | [Molecular Weight]
467.3 |
| Chemical Properties | Back Directory | [Boiling point ]
932.4±75.0 °C(Predicted) | [density ]
2.06±0.1 g/cm3(Predicted) | [storage temp. ]
-70°C | [solubility ]
H2O: ~10 mmol | [form ]
solid | [pka]
1.05±0.60(Predicted) | [color ]
white | [Water Solubility ]
H2O: ~10mmol |
| Hazard Information | Back Directory | [Uses]
PET-cGMP is a cyclic guanosine monophosphate analog and an effective selective agonist of PKG I, the EC50 of PET-cGMP for PKG Iβ is 3.8 nM, while for PKG II, it's 193 nM[1]. | [Biochem/physiol Actions]
cGMP-dependent protein kinase (PKG I and PKG II) activator. Potent membrane permeant activator of both isozymes I α and I β of cGMP-dependent protein kinase. Common stimulators such as 8-Br-cGMP or 8-pCPT-cGMP mainly activate kinase subtype Iα. | [References]
[1] James C Campbell, et al. Structural Basis of Analog Specificity in PKG I and II. ACS Chem Biol. 2017 Sep 15;12(9):2388-2398. DOI:10.1021/acschembio.7b00369 |
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