| Identification | Back Directory | [Name]
(trans)-4-PPC | [CAS]
78165-07-8 | [Synonyms]
(trans)-4-PPC
KPRUAZBLIREHPD-QAQDUYKDSA-N
ac trans-4’-Hydroxy Phencyclidine
rac trans-4'-Hydroxy Phencyclidine
trans-4-Phenyl-4-piperidinocyclohexanol
4-Phenyl-4-(piperidin-1-yl)cyclohexan-1-ol
2H5]-trans-4-Phenyl-4-piperidinocyclohexanol
trans-4-Phenyl-4-(1-piperidinyl)cyclohexanol
rac trans-4-Phenyl-4-(1-piperidinyl)cyclohexanol
trans-1-(1-Phenyl-4-hydroxycyclohexyl)piperidine | [Molecular Formula]
C17H25NO | [MOL File]
78165-07-8.mol | [Molecular Weight]
259.39 |
| Chemical Properties | Back Directory | [Boiling point ]
382.5±42.0 °C(Predicted) | [density ]
1.093±0.06 g/cm3(Predicted) | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
15.10±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
trans-4-phenyl-4-Piperidinocyclohexanol (Item No. 20565) is an analytical reference standard that is structurally categorized as an arylcyclohexylamine. It is a metabolite of phencyclidine (PCP; ). trans-4-phenyl-4-Piperidinocyclohexanol inhibits dopamine uptake in rat striatal synaptosomes to a similar extent as PCP. This product is intended for research and forensic applications. | [Uses]
trans-4-Phenyl-4-(1-piperidinyl)cyclohexanol [(trans)-4-PPC] is the trans-isomer of the 4-hydroxy(cyclo) metabolite of Phencyclidine (P295502). Studies show that (trans)-4-PPC elicits dose-related increases in locomotor activity and rearing in mice, and (trans)-4-PPC may also be involved in psychotomimetic effects of PCP due to its inhibitory effect on DA uptake. | [Definition]
ChEBI: Trans-4-Phenyl-4-piperidinocyclohexanol is a member of cyclohexanols. | [References]
[1] T SAKAMOTO Y N A Tanaka. Hair analysis for drugs of abuse XII. Determination of PCP and its major metabolites, PCHP and PPC, in rat hair after administration of PCP.[J]. Journal of analytical toxicology, 1996, 20 2: 124-130. DOI: 10.1093/jat/20.2.124
[2] ATSUOMI BABA . Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol, on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding and [3H]dopamine uptake in the rat brain[J]. Neuroscience Letters, 1994, 182 1: Pages 119-121. DOI: 10.1016/0304-3940(94)90221-6 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|