| Identification | Back Directory | [Name]
3-BROMO-4-FLUOROBENZYL BROMIDE | [CAS]
78239-71-1 | [Synonyms]
3-Bromo-4-fluorobenzyl Bromide >
2-BroMo-4-(broMoMethyl)-1-fluorobenzene
Benzene, 2-bromo-4-(bromomethyl)-1-fluoro-
2-Bromo-4-(bromomethyl)-1-fluorobenzene, alpha,3-Dibromo-4-fluorotoluene | [Molecular Formula]
C7H5Br2F | [MDL Number]
MFCD09037367 | [MOL File]
78239-71-1.mol | [Molecular Weight]
267.93 |
| Chemical Properties | Back Directory | [Melting point ]
41 °C | [Boiling point ]
259.8±25.0 °C(Predicted) | [density ]
1.923±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
soluble in Methanol | [form ]
Solid | [color ]
White | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Lachrymatory |
| Hazard Information | Back Directory | [Uses]
3-Bromo-4-fluorobenzyl bromide is used as a pharmaceutical intermediate. | [Synthesis]
General procedure for the synthesis of 3-bromo-4-fluorobenzyl bromide from 3-bromo-4-fluorotoluene: 3-bromo-4-fluorotoluene (6 mL, 48 mmol) and N-bromosuccinimide (2.7 g, 15 mmol) were dissolved in 1,2-dichloroethane, followed by the addition of 2,2'-azobisisobutyronitrile (16 mg, 0.1 mmol) to a 1,2-dichloroethane solution ( 10 mL). The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, diluted with 1,2-dichloroethane (40 mL) and washed with water (2 x 50 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated to a small volume under reduced pressure. The product 3-bromo-4-fluorobenzyl bromide was obtained (yield: 9.2 g, 72% yield). | [References]
[1] Patent: US2009/69320, 2009, A1. Location in patent: Page/Page column 71
[2] Journal of medicinal chemistry, 1967, vol. 10, # 1, p. 64 - 66
[3] Patent: US6586633, 2003, B1 |
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