78397-15-6

66512-37-6

78397-15-6

The general procedure for the synthesis of (R)-[(1-phenylethyl)amino]acetic acid from ethyl (R)-(1-phenylethylamino)acetate was as follows: the product of Example 14A (4.5 g, 15.6 mmol) was dissolved in water (100 mL) and heated and refluxed for 18 hours. Upon completion of the reaction, the reaction mixture was cooled to 30 °C and subsequently concentrated under reduced pressure to afford the target product (R)-[(1-phenylethyl)amino]acetic acid as a white solid (2.7 g, 80% yield). Mass spectrometry analysis (DC1/NH3) showed m/z 180 (M+H)+, confirming the structure of the product.