| Identification | Back Directory | [Name]
Cdk/Crk Inhibitor | [CAS]
784211-09-2 | [Synonyms]
RGB-286147
Cdk/Crk Inhibitor
RGB 286147,RGB286147 | [Molecular Formula]
C23H22Cl2N4O3 | [MDL Number]
MFCD28138127 | [MOL File]
784211-09-2.mol | [Molecular Weight]
473.35 |
| Chemical Properties | Back Directory | [Boiling point ]
677.0±65.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml | [form ]
White powder solid. | [pka]
14.23±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Cdk/Crk Inhibitor is a pyrazolo-pyrimidinone compound that acts as a potent, selective & ATP-competitive inhibitor of Cdks. | [Biological Activity]
Cell permeable: yes''Primary Target
Cdk1/BCdk2/ECdk3/ECdk5/p35Cdk7/H/MAT1and Cdk9''Product competes with ATP.''Reversible: no''Target IC50: 48 nM15 nM9 nM10 nM71 nMand 9 nM for Cdk1/BCdk2/ECdk3/ECdk5/p35Cdk7/H/MAT1and Cdk9respectively | [IC 50]
CDK1/cyclinB: 48 nM (IC50); CDK2/E: 15 nM (IC50); CDK4/D1: 839 nM (IC50); cdk6/cyclin D3: 232 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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