784211-09-2

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784211-09-2 Structure

Identification	Back Directory
[Name] Cdk/Crk Inhibitor
[CAS] 784211-09-2
[Synonyms] RGB-286147 Cdk/Crk Inhibitor RGB 286147,RGB286147
[Molecular Formula] C23H22Cl2N4O3
[MDL Number] MFCD28138127
[MOL File] 784211-09-2.mol
[Molecular Weight] 473.35

Chemical Properties	Back Directory
[Boiling point ] 677.0±65.0 °C(Predicted)
[density ] 1.42±0.1 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[solubility ] DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
[form ] White powder solid.
[pka] 14.23±0.10(Predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Uses] Cdk/Crk Inhibitor is a pyrazolo-pyrimidinone compound that acts as a potent, selective & ATP-competitive inhibitor of Cdks.
[Biological Activity] Cell permeable: yes''Primary Target Cdk1/BCdk2/ECdk3/ECdk5/p35Cdk7/H/MAT1and Cdk9''Product competes with ATP.''Reversible: no''Target IC50: 48 nM15 nM9 nM10 nM71 nMand 9 nM for Cdk1/BCdk2/ECdk3/ECdk5/p35Cdk7/H/MAT1and Cdk9respectively
[IC 50] CDK1/cyclinB: 48 nM (IC₅₀); CDK2/E: 15 nM (IC₅₀); CDK4/D1: 839 nM (IC₅₀); cdk6/cyclin D3: 232 nM (IC₅₀)
[storage] Store at -20°C

784211-09-2 suppliers list

Company Name:	Shanghai EFE Biological Technology Co., Ltd.
Tel:	021-65675885 18964387627
Website:	http://www.efebio.com

Company Name:	Shanghai Hongye Biotechnology Co. Ltd
Tel:	400-9205774
Website:	www.glpbio.cn

Company Name:	ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel:	18818260767
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Company Name:	Shanghai Yiyan Biotechnology Co. , Ltd.
Tel:	021-69985186 13611928337
Website:	www.chemicalbook.com/ShowSupplierProductsList1691458/0_EN.htm

Company Name:	Santa Cruz Biotechnology Inc
Tel:	021-60936350
Website:	www.scbt.com

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