| Identification | Back Directory | [Name]
3-DEAZA-2'-DEOXYADENOSINE | [CAS]
78582-17-9 | [Synonyms]
Aids002055
Aids-002055
3-Deaza-2'-da
3-DEAZA-2'-DEOXYADENOSINE
1H-Imidazo[4,5-c]pyridin-4-amine, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-
1H-Imidazo[4,5-C]pyridin-4-amine, 1-(2'-deoxy-.beta.-D-erythro-pentofuranosyl)- | [Molecular Formula]
C11H14N4O3 | [MDL Number]
MFCD08062098 | [MOL File]
78582-17-9.mol | [Molecular Weight]
250.25 |
| Chemical Properties | Back Directory | [Melting point ]
208-209 °C | [Boiling point ]
617.7±65.0 °C(Predicted) | [density ]
1.75±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [pka]
13.88±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity[1][2]. | [storage]
Store at -20°C | [References]
[1] Hendrickson CL, et al. Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. Nucleic Acids Res. 2004 Apr 23;32(7):2241-50. DOI:10.1093/nar/gkh542
[2] Cristalli G, et al. Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. J Med Chem. 1995 Sep 29;38(20):4019-25. DOI:10.1021/jm00020a017 |
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