| Identification | Back Directory | [Name]
3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one | [CAS]
79098-75-2 | [Synonyms]
3-piperidin-4-yl-1,4-dihydroquinazolin-2-one
3-(4-piperidinyl)-1,4-dihydroquinazolin-2-one
3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one
3,4-dihydro-3-(4-piperidinyl)-2(1H)-Quinazolinone
3-(4-Piperidinyl)-3,4-dihydro-2(1H)-quinazolinone
3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one
(1H)-quinazolinone, 3,4-dihydro-3-(4-piperidinyl)-
2(1H)-Quinazolinone, 3,4-dihydro-3-(4-piperidinyl)-
3,4-DIHYDRO-3-(4-PIPERIDINYL)-2(1H)-QUINAZOLINONE HCL
3-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one
3-(Piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one 95+% | [Molecular Formula]
C13 H17 N3 O | [MDL Number]
MFCD11043062 | [MOL File]
79098-75-2.mol | [Molecular Weight]
231.29 |
| Chemical Properties | Back Directory | [Boiling point ]
459.0±45.0 °C(Predicted) | [density ]
1.180±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
14.85±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
3-(1-benzylpiperidin-4-yl)-3,4-dihydro-1H-quinazolin-2-one (1.2 g, 3.7 mmol) was used as starting material, which was dissolved in 30 mL of methanol and pre-gassed with nitrogen. Subsequently, 120 mg of palladium carbon (10 wt%) catalyst was added to the solution. The reaction mixture was placed under hydrogen atmosphere and stirred at room temperature for 48 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford 0.9 g (100% yield) of the white solid product 3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one. | [References]
[1] Patent: US2018/50992, 2018, A1. Location in patent: Paragraph 0404
[2] Patent: US2005/192230, 2005, A1. Location in patent: Page/Page column 5
[3] Patent: WO2005/77931, 2005, A2. Location in patent: Page/Page column 12-13
[4] Patent: US6344/449, 2002, B1. Location in patent: Example A4f)
[5] Patent: US6344449, 2002, B1. Location in patent: Example A4f) |
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