| Identification | Back Directory | [Name]
6-FLUOROQUINOLIN-2-AMINE | [CAS]
791626-57-8 | [Synonyms]
6-FLUORO-2-QUINOLINAMINE
6-FLUOROQUINOLIN-2-AMINE
6-FLUORO-2-QUINOLINEAMINE
2-Amino-6-fluoroquinoline
2-Quinolinamine, 6-fluoro-
2-Quinolinamine,6-fluoro-(9CI) | [Molecular Formula]
C9H7FN2 | [MDL Number]
MFCD07368132 | [MOL File]
791626-57-8.mol | [Molecular Weight]
162.16 |
| Chemical Properties | Back Directory | [Melting point ]
141-148 °C | [Boiling point ]
308.6±22.0 °C(Predicted) | [density ]
1.315±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
5.96±0.43(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Tert-butyl 6-fluoroquinolin-3-ylcarbamate (1.3 g, 4.95 mmol) was used as starting material, which was dissolved in 1,2-dichloroethane (15 mL), followed by trifluoroacetic acid (15 mL) and water (1 mL). The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was ground with ether. The resulting solid was purified by fast chromatography with the eluent being a 2N ammonia methanol solution in dichloromethane (gradient: 0% to 3%) to afford 6-chloroquinolin-2-amine as a colorless solid in a yield of 0.47 g (59% yield). Mass spectrometry (MS) analysis showed m/z 162.9 (MH+). | [References]
[1] Patent: WO2004/69792, 2004, A2. Location in patent: Page 169-170 |
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| Company Name: |
Cochemical Ltd.
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| Telephone: |
029-86115547 17791676824 |
| Website: |
http://www.cochemical.com |
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