| Identification | Back Directory | [Name]
N-METHYL PROTOPORPHYRIN IX | [CAS]
79236-56-9 | [Synonyms]
Aids006240
Aids-006240
N-METHYL PROTOPORPHYRIN IX
7,12-Diethenyl-3,8,13,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17,23-pentamethyl- | [Molecular Formula]
C35H36N4O4 | [MDL Number]
MFCD08669600 | [MOL File]
79236-56-9.mol | [Molecular Weight]
576.68 |
| Hazard Information | Back Directory | [Description]
N-methyl Protoporphyrin IX is a transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway. It is used to study the effect of heme synthesis blockade in cell systems. | [Uses]
N-Methylprotoporphyrin IX is a potent inhibitor of ferrochelatase enzyme[1]. | [References]
[1] Ortiz de Montellano PR, et al. Inhibition of hepatic ferrochelatase by the four isomers of N-methylprotoporphyrin IX. Biochem Biophys Res Commun. 1980;97(4):1436-1442. DOI:10.1016/s0006-291x(80)80026-x |
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