| Identification | Back Directory | [Name]
ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate | [CAS]
792946-69-1 | [Synonyms]
DCLX069
DCLX-069
DCLX 069
ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate
PRMT1,Inhibitor,anticancer,Histone Methyltransferase,DCLX069,inhibit | [Molecular Formula]
C20H25N3O2 | [MDL Number]
MFCD06666140 | [MOL File]
792946-69-1.mol | [Molecular Weight]
339.43 |
| Chemical Properties | Back Directory | [Boiling point ]
515.9±50.0 °C(Predicted) | [density ]
1.179±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
7.45±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 μM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1]. | [IC 50]
PRMT1: 17.9 μM (IC50) | [References]
[1] Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org Biomol Chem. 2014 Dec 21;12(47):9665-73. DOI:10.1039/c4ob01591f |
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Specs
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