| Identification | Back Directory | [Name]
3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] | [CAS]
79386-00-8 | [Synonyms]
Destruxin B2
3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] | [Molecular Formula]
C29H49N5O7 | [MOL File]
79386-00-8.mol | [Molecular Weight]
579.74 |
| Chemical Properties | Back Directory | [Boiling point ]
870.7±65.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: 10 mg/ml; DMSO: 10 mg/ml | [pka]
13.44±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities. It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM). Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM. It is also phytotoxic to B. napus leaves. | [Uses]
Destruxin B2 (compound 5) is a natural depsipeptide that can be inhibits hepatitis B surface antigen (HBsAg) secretion in Hep3B cells with an IC50 1.30 μM[1]. | [References]
[1] Yeh SF, et al. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem Biophys Res Commun. 1996 Dec 4;229(1):65-72. DOI:10.1006/bbrc.1996.1758 |
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