| Identification | Back Directory | [Name]
20-carboxyarachidonic acid | [CAS]
79551-84-1 | [Synonyms]
20-carboxyarachidonic acid
(5Z,8Z,11Z,14Z)-icosatetraenedioic acid
5(Z),8(Z),11(Z),14(Z)-eicosatetraenedioic acid | [Molecular Formula]
C20H30O4 | [MOL File]
79551-84-1.mol | [Molecular Weight]
334.45 |
| Chemical Properties | Back Directory | [Boiling point ]
500.7±38.0 °C(Predicted) | [density ]
1.037±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 1.5 mg/ml; DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml | [pka]
4.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system. | [Uses]
20-carboxy Arachidonic Acid is a PPARα and PPARγ activator. | [Definition]
ChEBI: An alpha,omega-dicarboxylic acid that is (5Z,8Z,11Z,14Z)-icosatetraene in which the two methyl groups are replaced by carboxy groups. | [storage]
Store at -20°C | [References]
[1] XIANG FANG . 20-Carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ[J]. Prostaglandins & other lipid mediators, 2007, 82 1: Pages 175-184. DOI: 10.1016/j.prostaglandins.2006.05.002 |
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