| Identification | Back Directory | [Name]
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH | [CAS]
79994-24-4 | [Synonyms]
YGGFLRRIRP
DYNORPHIN A (1-10)
Porcine dynorphin A(1-10)
DYNORPHIN A (1-10), PORCINE
dynorphin A, porcine, fragment 1-10
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO
dynorphin A fragment 1-10 porcine*sequence
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST | [Molecular Formula]
C57H91N19O12 | [MDL Number]
MFCD00076363 | [MOL File]
79994-24-4.mol | [Molecular Weight]
1234.45 |
| Hazard Information | Back Directory | [Uses]
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM. | [IC 50]
NMDA Receptor; κ Opioid Receptor/KOR | [References]
[1] Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62. DOI:10.1021/jm970252j
[2] Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31. PMID:9495839 |
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