| Identification | Back Directory | [Name]
THEOPHYLLOL | [CAS]
8002-89-9 | [Synonyms]
THEOPHYLLOL
THEOPHENYLLOL
ionesodiumsalt
theocinsoluble
acet-theocinsodium
THEOPHYLLINE SODIUM ACETATE
theophyllinumnatriumaceticum
7-Theophyllineacetic acid sodium salt
theophylline,compd.withsodiumacetate(1:1)
aceticacid,sodiumsalt,compd.withtheophylline(1:1)
aceticacid,sodiumsalt,mixt.with3,7-dihydro-1,3-dimethyl-1h-purine-2,6-d | [Molecular Formula]
C9H10N4Na2O4 | [MDL Number]
MFCD00145398 | [MOL File]
8002-89-9.mol | [Molecular Weight]
284.18 |
| Hazard Information | Back Directory | [Uses]
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. | [in vivo]
Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO[1]. | Animal Model: | Male Swiss mice[1] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection; daily, for 9 days | | Result: | Increased IL-6 and IL-10 levels and inhibited TNF-α and NO. |
| [IC 50]
IL-10; IL-6; PDE3; Human Endogenous Metabolite | [References]
[1] Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. PMID:7664866
[2] Chung IY, et, al. The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil. Cell Immunol. 2000 Aug 1;203(2):95-102. DOI:10.1006/cimm.2000.1678
[3] Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):558-61. DOI:10.1007/s00210-001-0494-x
[4] Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. DOI:10.1073/pnas.132556899
[5] Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. DOI:10.1164/rccm.201302-0388PP |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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