| Identification | Back Directory | [Name]
D-87503 | [CAS]
800394-83-6 | [Synonyms]
D-87503
D-87503/D87503
1-allyl-3-(3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl)thiourea
N-[3-(4-Hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]-N'-2-propen-1-ylthiourea
Thiourea, N-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]-N'-2-propen-1-yl- | [Molecular Formula]
C17H15N5OS | [MDL Number]
MFCD17169986 | [MOL File]
800394-83-6.mol | [Molecular Weight]
337.4 |
| Hazard Information | Back Directory | [Uses]
D-87503 is a potent inhibitor of PI3k/Akt/mTOR, with the IC50s of 62 nM and 0.76 μM, respectively for PI3k and Erk2. D-87503 effectively suppressed the target downstream substrates Akt and Rsk1 kinase of the PI3k/Akt/mTOR signaling pathway[1]. | [References]
[1] Mukesh Chandra Joshi, et al. Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology. Review Curr Drug Discov Technol. 2014 Jun;11(2):113-26. DOI:10.2174/1570163810666131229130207 |
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