| Identification | Back Directory | [Name]
A 33853 | [CAS]
80148-45-4 | [Synonyms]
A 33853
Antibiotic A 33853
2-(3-Hydroxy-2-(3-hydroxypicolinamido)phenyl)-benzo[d]oxazole-4-carboxylic acid
2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)-amino]-phenyl]-benzoxazole-4-carboxylic acid
2-[3-HYDROXY-2-[[(3-HYDROXY-2-PYRIDINYL)CARBONYL]AMINO]PHENYL]-4-BENZOXAZOLECARBOXYLIC ACID
4-Benzoxazolecarboxylic acid, 2-[3-hydroxy-2-[[(3-hydroxy-2-pyridinyl)carbonyl]amino]phenyl]- | [Molecular Formula]
C20H13N3O6 | [MDL Number]
MFCD01939450 | [MOL File]
80148-45-4.mol | [Molecular Weight]
391.33 |
| Hazard Information | Back Directory | [Uses]
Antibiotic A-338533, an antibiotic, can be isolated from Streptomyces strain. Antibiotic A-338533 has anti-bacterial activity against Staphylococcus aureus, Mycoplasma gallisepticum with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively[1]. | [in vivo]
Antibiotic A-33853 (60 mg/kg; s.c.; single dose) is inactive against Mycoplasma gallisepticum in chicks in vivo[1].
Antibiotic A-33853 (70 mg/kg; s.c.; twice doses) is ineffective against S. aureus in mice in vivo[1].
Antibiotic A-33853 has an acute toxic dose with a LD50 value >300 mg/kg (i.p.) on mice model[1].
| [References]
[1] In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes
J. Med. Chem., 2008, 51 (23), pp 7344-7347
[2] Michel KH, et al. The discovery, fermentation, isolation, and structure of antibiotic A33853 and its tetraacetyl derivative. J Antibiot (Tokyo). 1984 May;37(5):441-5. DOI:10.7164/antibiotics.37.441 |
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