| Identification | Back Directory | [Name]
DIGITALIS (3 G) | [CAS]
8031-42-3 | [Synonyms]
digitol
FOXGLOVE
digitalone
digitannoid
DIGITALISLANATA
DIGITALIS (3 G)
digitalispurpurea,leaf
digitalin(pharmaceutical)
digitalis,naturalproducts,pharmaceutical | [MDL Number]
MFCD01771767 |
| Hazard Information | Back Directory | [Uses]
Digitalis USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. | [Biological Functions]
Lanatoside A is composed of the aglycone digitoxigenin (genin indicates no sugar) connected to
three digitoxose sugar molecules, the third of which carries a 3-acetyl group, and a terminal glucose
molecule. In other words, the structure sequence is glucose4-3-acetyldigitoxose3-digitoxose2-
digitoxose1-digitoxigenin.
Lanatoside B has the identical sugar portion to lanatoside A, except that the aglycone has extra
hydroxyl group at C-16 and is given the name gitoxigenin. The structural sequence is glucose4-3-
acetyldigitoxose3-digitoxose2-digitoxose1-gitoxigenin.
Lanatoside C also has the same sugars found in both lanatosides A and B; however, the aglycone
has the nucleus of lanatoside A plus an additional hydroxyl group at C-12. This cardenolide is
named digoxigenin. The structural sequence is glucose4-3-acetyldigitoxose3-digitoxose2-digitoxose1-
digoxigenin.
Partial hydrolysis of the glucose molecule and the acetate group from lanatoside A and C produces,
respectively, two new and most important cardiac glycosides, digitoxin and digoxin, with the
following sequences: digitoxin, (digitoxose)3-digitoxigenin; and digoxin, (digitoxose)3-digoxigenin. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Whyte Chemicals
|
| Tel: |
+44 (20) 8346-5946 |
| Website: |
www.whytechemicals.co.uk |
|