| Identification | Back Directory | [Name]
[D-PRO2, D-TRP7,9]-SUBSTANCE P | [CAS]
80434-86-2 | [Synonyms]
dt79
Pt-sp
Pttsp
(D-pro2
2,D-Trp7,9>-SP
(D-Pro2,D-Trp7
2-Pro-7,9-Trp-sp
2-Pro-7,9-Trp-substance p
Substance p, Pro(2)-Trp(7,9)-
[D-PRO2, D-TRP7,9]-SUBSTANCE P
[D-PRO2,D-TRP7,9]-SUBSTANCE P 3HCL 6H2O
substance P, prolyl(2)-tryptophan(7,9)-
Substance P, (D-Pro2, D-Trp7,9) acetate
[D-PRO2,D-TRP7,9]-SUBSTANCE P HYDROCHLORIDE
17:PN:US20020037833 SEQID:16 unclaimed sequence
ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
H-Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
Substance p, 2-D-proline-7-D-tryptophan-9-D-tryptophan-
ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 3HCL 6H2O
ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 HYDROCHLORIDE
L-Arg-D-Pro-L-Lys-L-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
L-Arg-D-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
L-Methioninamide, L-arginyl-D-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl- | [Molecular Formula]
C74H106N20O13S | [MDL Number]
MFCD00076808 | [MOL File]
80434-86-2.mol | [Molecular Weight]
1515.82 |
| Hazard Information | Back Directory | [Uses]
[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2]. | [in vivo]
[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1].
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2]. | Animal Model: | Adult pigmented rabbits (1.5-3 kg)[1] | | Dosage: | 0.03, 0.3, 3, and 30 nmol | | Administration: | Intravitreal injection or topical application onto the eye, 60 μL | | Result: | Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye. |
| [References]
[1] Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. DOI:10.1126/science.6171036
[2] H?kanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. DOI:10.1111/j.1476-5381.1982.tb09348.x
[3] Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. DOI:10.5114/fn.2020.100066 |
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