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80443-12-5

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80443-12-5 Structure

80443-12-5 Structure

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[Name] 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2,3-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-
[CAS] 80443-12-5
[Synonyms] AChE/BChE-IN-11 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2,3-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-
[Molecular Formula] C21H22O12
[MOL File] 80443-12-5.mol
[Molecular Weight] 466.39

Chemical Properties	Back Directory
[Boiling point ] 871.1±65.0 °C(Predicted)
[density ] 1.82±0.1 g/cm3(Predicted)
[pka] 7.33±0.60(Predicted)

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[Uses] AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and BChE inhibitor with IC50 values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research[1].
[IC 50] AChE: 70 μM (IC₅₀); BChE: 71 μM (IC₅₀)
[References] [1] Elsebai MF, et, al. X-ray crystalographic data, absolute configuration, and anticholinesterase effect of dihydromyricitrin 3-O-rhamnoside. Sci Rep. 2022 Nov 1;12(1):18351. DOI:10.1038/s41598-022-23240-7

80443-12-5 suppliers list

Company Name:	Biorbyt Ltd.
Telephone:	+44 (0)1223 859 353
Website:	http://www.biorbyt.com

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