| Identification | Back Directory | [Name]
(1S,2S,3aR,4S,5S,6E,9R,11R,12E,13aS)-1,2,3,4,5,8,9,10,11,13a-Decahydro-2,5,8,8,12-pentamethyl-3aH-cyclopentacyclododecene-1,3a,4,9,11-pentol 4,9,11-triacetate 1-benzoate | [CAS]
80454-47-3 | [Synonyms]
Euphornin
(1S,2S,3aR,4S,5S,6E,9R,11R,12E,13aS)-1,2,3,4,5,8,9,10,11,13a-Decahydro-2,5,8,8,12-pentamethyl-3aH-cyclopentacyclododecene-1,3a,4,9,11-pentol 4,9,11-triacetate 1-benzoate
3aH-Cyclopentacyclododecene-1,3a,4,9,11-pentol, 1,2,3,4,5,8,9,10,11,13a-decahydro-2,5,8,8,12-pentamethyl-, 4,9,11-triacetate 1-benzoate, (1S,2S,3aR,4S,5S,6E,9R,11R,12E,13aS)- | [Molecular Formula]
C33H44O9 | [MOL File]
80454-47-3.mol | [Molecular Weight]
584.7 |
| Chemical Properties | Back Directory | [Melting point ]
255-258 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
624.1±55.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.32±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein[1]. | [References]
[1] Li XQ, et al. Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest. Onco Targets Ther. 2018 Jul 27;11:4395-4405. DOI:10.2147/OTT.S166018 |
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