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8052-16-2

8052-16-2 Structure

8052-16-2 Structure
IdentificationBack Directory
[Name]

ACTINOMYCIN C
[CAS]

8052-16-2
[Synonyms]

hbf386
nsc-18268
sanamicia
sanamycin
CACTINOMYCIN
actinochrysin
ACTINOMYCIN C
Actinochrysin C
ACTINOMYCIN C USP/EP/BP
ACTINOMYCIN C FROM STREPTOMYCES &
ACTINOMYCIN C, STREPTOMYCES CHRYSOMALLUS
mixtureofdactinomycin(10%),actinomycinc2(45%),andactinomycinc3(45%)
[EINECS(EC#)]

232-485-1
[MDL Number]

MFCD00070921
Chemical PropertiesBack Directory
[Melting point ]

252°
[alpha ]

D25 -325 to -349° (c = 0.25 in ethanol)
[Boiling point ]

848.87°C (rough estimate)
[density ]

1.0721 (rough estimate)
[refractive index ]

1.6000 (estimate)
[storage temp. ]

2-8°C
[Merck ]

13,1606
Safety DataBack Directory
[Hazard Codes ]

T+
[Risk Statements ]

46-61-26/27/28
[Safety Statements ]

53-36/37/39-45
[RIDADR ]

UN 3462 6.1/PG 2
[WGK Germany ]

3
[RTECS ]

AU1400000
[F ]

8-10-21
[HazardClass ]

6.1(a)
[PackingGroup ]

II
Hazard InformationBack Directory
[Uses]

Actinomycin C is an antibiotic produced by?Streptomyces chrysomallus that intercalates DNA.
[Uses]

Antineoplastic.
[Purification Methods]

(A commercial mixture of Actinomycin C1 5%, C2 30% and C3 65% is available). Actinomycin C1 (native) crystallises from EtOAc as red crystals, is soluble in CHCl3, *C6H6 and Me2CO, and has m 246-247o(dec), [] 20D -328o (0.22, MeOH) and max 443nm ( 25,000) and 240nm ( 34,000). Actinomycin C2 (native) crystallises as red needles from EtOAc and has m 244-246o(dec), [] D -325o (c 0.2, MeOH), max 443nm ( 25,300) and 240nm ( 33,400). Actinomycin C3 (native) recrystallises from cyclohexane, or *C6H6/MeOH/cyclohexane as red needles with m 238-241o (dec), [] D -321o (c 0.2, MeOH), max 443nm ( 25,000) and 240nm ( 33,300). [Brockman & Lackner, Chem Ber 101 1312 1968.] Itis light sensitive.[Beilstein 27 III/IV 9642.]
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