| Identification | Back Directory | [Name]
LENAMPICILLIN HYDROCHLORIDE | [CAS]
80734-02-7 | [Synonyms]
kb1585
kbt1585
kbt-1585
takacillin
varacillin
LENAMPICILLIN
LenampicillinHCl
KBT-1585 HYDROCHLORIDE
Lempicillin hydrochloride
Lenanpicillin hydrochloride
LENAMPICILLIN HYDROCHLORIDE
-2-carboxylicacid,hydrochloride
Lenampicillin hydrochloride
(KBT-1585 hydrochloride)
ampicillin,(5-methyl-2-oxo-1,3-dioxolen-4-yl)methylester,hydrochloride
carbonicacid,cyclic1-(hydroxymethyl)-2-methylethyleneester,esterwith6-(2
(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-d-alpha-aminobenzylpenicillinatehyd
-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane
(2S,5R,6R)-6-[[(2R)-AMinophenylacetyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Ester Hydrochloride
[2S-[2α,5α,6β(S*)]]-6-[(AMinophenylacetyl)aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Ester MonoHydrochloride
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, monohydrochloride, [2S-[2a,5a,6b(S*)]]-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, monohydrochloride, (2S,5R,6R)- (9CI) | [Molecular Formula]
C21H23N3O7S | [MDL Number]
MFCD00865124 | [MOL File]
80734-02-7.mol | [Molecular Weight]
461.49 |
| Chemical Properties | Back Directory | [Melting point ]
145° (dec) | [storage temp. ]
Store at -20°C, sealed storage, away from moisture and light | [solubility ]
DMSO:100.0(Max Conc. mg/mL);200.82(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Lenampicillin is an oral ampicillin prodrug. Antibiotic used in the treatment of respiratory tract infections and urinary tract infections.
| [Definition]
ChEBI: Valacillin (TN) is a peptide. | [in vivo]
Lenampicillin hydrochloride (KBT-1585) (oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis[2].Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver[3]. |
| Safety Data | Back Directory | [Toxicity]
LD50 in male, female rats, male, female mice (mg/kg): approx 10000, approx 10000, 8294, 8492 orally; 4362, 4471, 3576, 4284 s.c.; 876, 838, 711, 775 i.v.; in dogs (mg/kg): >300 orally (Ogino) |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
cjbscvictory
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| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
ChemeGen
|
| Telephone: |
18818260767 |
| Website: |
https://www.chemegen.com |
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