| Hazard Information | Back Directory | [Description]
A778317 is a novel, stereoselective, high-affinity antagonist. | [Uses]
A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid[1]. | [References]
[1] Bianchi B R, et al. [3H] A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 323(1): 285-293. |
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