| Identification | Back Directory | [Name]
Sennoside A | [CAS]
81-27-6 | [Synonyms]
PURSENNID
SENNOSIDE
SENNOSIDA
Glysennid
GLYSENNIDE
Nsc 112929
PURSENNIDE
SENNOSIDE A
Tomato juice
Sennoside A1
SENNOSIDEA60%
Sennoside USP
Gentle Nature
SENNOSIDE A(P)
SENNOSIDE A(SH)
SENNIDINE A(RG)
Einecs 201-339-9
SENNOSIDE A hplc
Sennoside A std.
Sennoside A ,98%
Sennoside A (20 mg)
SENNOSIDE A WITH HPLC
CALCIUM SENNOSIDE 5%, 10%, 20%, 60%
11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid,11,12-EET
[9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'R)-
Sennoside A (20 mg) ((9R,9'R)-5,5'-Bis(beta-d-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid) | [EINECS(EC#)]
201-339-9 | [Molecular Formula]
C42H38O20 | [MDL Number]
MFCD00151527 | [MOL File]
81-27-6.mol | [Molecular Weight]
862.74 |
| Chemical Properties | Back Directory | [Melting point ]
>191oC (dec.) | [alpha ]
D20 -164° (c = 0.1 in 60% acetone); D20 -147° (c = 0.1 in 70% acetone); D20 -24° (c = 0.2 in 70% dioxane) | [Boiling point ]
1144.8±65.0 °C(Predicted) | [density ]
1.743±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated) | [form ]
neat | [pka]
3.31±0.40(Predicted) | [color ]
Yellow to Dark Yellow | [BRN ]
5723746 | [Stability:]
Hygroscopic | [Major Application]
food and beverages | [InChIKey]
IPQVTOJGNYVQEO-KGFNBKMBSA-N | [LogP]
1.880 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Usage]
a natural anthroquinonone glucoside calcium complex with laxative properties | [Uses]
a natural anthroquinonone glucoside calcium complex with laxative properties | [Uses]
Sennoside A is used as a laxative in the treatment of constipation. In addition. it is hypothesized to induce cell proliferation and may be a potential carcinogenic agent. | [Definition]
ChEBI: Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. It is a member of sennosides and an oxo dicarboxylic acid. | [in vivo]
Sennoside A (25 mg/kg, 50 mg/kg; intragastric gavage for 12 weeks) alters the gut microbiome composition of type 2 diabetes (T2D) mice and mediates anti-obesity effects[3].
Sennoside A also reduces inflammation and increases tight junction proteins in the ileum of genetically defective mice[3].
| [IC 50]
HIV-1 | [Purification Methods]
Sennoside A (bianthraquinonyl-bis-glucoside R,R-enantiomer) [81-27-6] M 862.7, m 220 -2 4 0o(dec), [ ] D -164o (c 0.1, Me2CO/H2O 6:4), [ ] D -24o (c 0.2, 70% aqueous dioxane). Sennoside A forms yellow crystals from aqueous acetone, 2-ethoxyethanol or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3403.] |
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