| Identification | Back Directory | [Name]
Danshensu Sodium Salt | [CAS]
81075-52-7 | [Synonyms]
DS 182
Salianic acid A
Sodium Dahshensu
(R)-Sodium Danshensu
Danshensu Sodium Salt
13C6]-Danshensu sodium salt
(R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid
(R)-α,3,4-Trihydroxy-benzenepropanoic acid sodium salt
3-(3′,4′-Dihydroxyphenyl)-(2R)-lactic acid sodium salt | [Molecular Formula]
C9H11NaO5 | [MDL Number]
MFCD07781415 | [MOL File]
81075-52-7.mol | [Molecular Weight]
222.17 |
| Chemical Properties | Back Directory | [Melting point ]
>230°C (dec.) | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Optical Rotation]
[α]/D +30 to +40°, c = 1 in H2O | [Water Solubility ]
H2O: 20mg/mL, clear | [Stability:]
Hygroscopic | [InChI]
1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1/t8-;/m1./s1 | [InChIKey]
ZMMKVDBZTXUHFO-DDWIOCJRSA-M | [SMILES]
OC1=C(O)C=CC(C[C@@H](O)C([O-])=O)=C1.[Na+] |
| Hazard Information | Back Directory | [Uses]
Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain. | [Biochem/physiol Actions]
Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. Danshensu is cardioprotective, which protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. | [in vivo]
Danshensu (Dan shen suan A; 25, 50, 100?mg/kg; oral administration daily for 7 continuous days or i.v. once) sodium before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].
| Animal Model: | Adult BALB/c mice (male, 6-8 weeks, 20±2?g)[1] | | Dosage: | 25, 50, 100?mg/kg | | Administration: | Oral administration (daily for 7 continuous days) or i.v. (once) | | Result: | Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
BBT INC
|
| Tel: |
022-58613671 58613672 |
| Website: |
www.bestbiotech.com.cn |
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