| Identification | Back Directory | [Name]
L-GLUTAMIC ACID (1-13C) | [CAS]
81201-99-2 | [Synonyms]
Glu-1-13C
L-Glutamic acid-2-13C
L-GLUTAMIC ACID (1-13C)
13C Labeled L-glutamic acid
(S)-2-Aminopentanedioic acid-1-13C | [Molecular Formula]
C5H9NO4 | [MDL Number]
MFCD00144588 | [MOL File]
81201-99-2.mol | [Molecular Weight]
148.14 |
| Chemical Properties | Back Directory | [Melting point ]
205 °C (dec.)(lit.) | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
White to off-white | [optical activity]
[α]25/D +31°, c =2 in 5 M HCl |
| Hazard Information | Back Directory | [Uses]
L-Glutamic acid-1-13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. | [IC 50]
NMDA Receptor | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. DOI:10.1016/0304-3940(77)90068-4 |
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