| Identification | Back Directory | [Name]
1,4-Naphthalenedione, 2-acetyl-8-methoxy- | [CAS]
81418-42-0 | [Synonyms]
SARS-CoV MPro-IN-2
1,4-Naphthalenedione, 2-acetyl-8-methoxy- | [Molecular Formula]
C13H10O4 | [MOL File]
81418-42-0.mol | [Molecular Weight]
230.22 |
| Hazard Information | Back Directory | [Uses]
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 72.07 nM. The main protease (Mpro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19[1]. | [References]
[1] Cui J, et al. Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. Eur J Med Chem. 2021;225:113789. DOI:10.1016/j.ejmech.2021.113789 |
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