81486-22-8

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81486-22-8 Structure

Identification	Back Directory
[Name] NIPRADILOL
[CAS] 81486-22-8
[Synonyms] K 351 KT 210 Hypadil Nipranol Nipradolol NIPRADILOL Ccris 2515 Brn 3566879 Nipradolol (10mM in DMSO) NIPRANOL;NIPRADOLOL;NIPRADILOL;BRN 3566879 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanyl nitrat 8-(2-Hydroxy-3-(isopropylaMino)propoxy)chroMan-3-yl nitrate 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol 3-nitrate 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate 3,4-Dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran 3,4-Dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2H-1-benzopyran-3-ol 3-nitrate 3,4-Dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2H-1-benzopyran-3-ol 3-nitrate 2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate
[Molecular Formula] C15H22N2O6
[MDL Number] MFCD00864678
[MOL File] 81486-22-8.mol
[Molecular Weight] 326.34

Chemical Properties	Back Directory
[Melting point ] 110-122℃
[Boiling point ] 464.39°C (rough estimate)
[density ] 1.1829 (rough estimate)
[refractive index ] 1.6280 (estimate)

Hazard Information	Back Directory
[Description] Nipradilol is a beta-blocker with vasodilatory activity. As an antihypertensive nipradilol decreases systemic/pulmonary arterial blood pressure, heart rate, cardiac output and left ventricular volume without causing tachycardia. Nipradilol is also reported to have antiangina activity in dogs.
[Originator] Kowa (Japan)
[Uses] Nipradolol is a β-adrenoceptor blocking agent with antihypertensive properties.?Nipradolol is used as an?anti-glaucomatous agent.
[Definition] ChEBI: Hypadil (TN) is an organic molecular entity.
[Brand name] Hypadil

Safety Data	Back Directory
[Toxicity] LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988)

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