| Identification | Back Directory | [Name]
5-hydroxyeicosatetraenoic acid lactone | [CAS]
81517-87-5 | [Synonyms]
5-hydroxyeicosatetraenoic acid lactone
6-[(1E,3Z,6Z,9Z)-pentadeca-1,3,6,9-tetraenyl]oxan-2-one
2H-Pyran-2-one, tetrahydro-6-(1E,3Z,6Z,9Z)-1,3,6,9-pentadecatetraen-1-yl- | [Molecular Formula]
C20H30O2 | [MOL File]
81517-87-5.mol | [Molecular Weight]
302.45 |
| Chemical Properties | Back Directory | [Boiling point ]
445.7±34.0 °C(Predicted) | [density ]
0.979±0.06 g/cm3(Predicted) | [solubility ]
DMF: 50 mg/ml
DMSO: 50 mg/ml
Ethanol: 50 mg/mlPBS pH 7.2: 1 mg/ml | [form ]
Clear to light-yellow liquid. |
| Hazard Information | Back Directory | [Uses]
(±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation[1][2]. | [References]
[1] Tao C, et al. Reactivity of tricarbonyl (pentadienyl) iron (1+) cations: enantioselective synthesis of 5-HETE methyl ester[J]. The Journal of Organic Chemistry, 1993, 58(8): 2134-2143.
[2] Picardo C M. The hydrolysis of 5-HETE lactone by paraoxonase 1 and its stability in serum[M]. 2007. |
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