| Identification | Back Directory | [Name]
prothracarcin | [CAS]
81542-99-6 | [Synonyms]
DC-62
prothracarcin
Antibiotic DC-62
[11aS,2E,(+)]-2-Ethylidene-1,2,3,11aβ-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one
(2E,11R,11aS)-2-Ethylidene-11-hydroxy-1,2,3,10,11,11aβ-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one | [Molecular Formula]
C14H14N2O | [MOL File]
81542-99-6.mol | [Molecular Weight]
226.278 |
| Hazard Information | Back Directory | [Uses]
Prothracarcin is an antibiotic with antitumor activity that exerts its tumor cell toxicity by covalently binding to the C-2 amino group of guanine residues in the minor groove of DNA. Prothracarcin also shows antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Escherichia coli[1]. | [References]
[1] Fotso, et al. Limazepines A? F, Pyrrolo [1, 4] benzodiazepine Antibiotics from an Indonesian Micrococcus sp. Journal of natural products 72.4 (2009): 690-695. DOI:10.1021/np800827w |
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